Biomarkers of Aging and Disease: Introduction and Definitions.

The concept of biomarkers of aging and age-related disease began to appear in the gerontologic and geriatric literature in the early 1980s as investigators were wrestling with the disconnect between chronological age and lifespan across and within species. In those early days, the interest was in eliminating the confounding influence of disease from research on aging so that biomarkers of underlying processes of aging could be developed (Ludwig & Smoke, 1981; Reff & Schneider, 1982; Sprott & Schneider, 1985). The question of what was aging and what was disease was at the core of the development of scientific legitimacy for the young science of aging. A key question then (and in some places now) was whether aging and disease were separate entities or aging was simply the end result (sum of damage) of a lifetime of disease. Adherents of the "aging is disease" view held that biomarkers of aging, separate from disease were not possible. Adherents of the "aging is the result of basic underlying processes" argued that aging research needed to be conducted with disease free subjects (human and lower animal) in order to be valid. Biomarkers of aging would then be markers of the progress of these underlying processes.

Exp Gerontol. 2009 Jul 31
Biomarkers of Aging and Disease: Introduction and Definitions.
Sprott RL

4 comments:

Amarant said...

I didn't think aging biomakers are relatively new in the field of medical science. Didn't our ancestors already use physical signs that determined age?

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jonwilson said...

The way I see it, Amarant, what we have here is development that may very well lead to the lengthening of lifespans by manipulating aging biomarkers. Am I correct?

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smith john said...

Adherents of the "aging is disease" view held that biomarkers of aging, separate from disease were not possible Tetrabenazine. Adherents of the "aging is the result of basic underlying processes" argued that aging research needed to be conducted with disease free subjects

hcox said...

It is impossible for anything on Earth to be free of disease. There's a lesson in medicine that states: "Each human being is unique." While this is true, all human beings are subject to the same environmental pollutants and illness. What's unique is each body's reaction to these environmental agents. Therefore, aging, it's nature, course and effect will vary.

Hilda Cox